Gene Rubinstein, M.D., F.A.A.D.
(818) 505-9300

Depigmentation Treatments
Cosmelan® Depigmentation treatment is intended to dramatically reduce the
appearance of pigmentation and uneven skin tone resulting from Melasma,
acne scarring and other dermal pigmentation.  Cosmelan® has been
successful in addressing pigmentation previously non-responsive to
treatment.  This treatment has an in-office and an “at home” component.   
Cosmelan® has very high safety margin.

Cosmelan® Depigmentation treatment action mechanism is based on the
inhibition of tyrosinase, a basic enzyme in the melanin formation process.
Several of the substances present in the Cosmelan® formula act by blocking
this enzyme, or even by inverting the metabolic process of the transformation

Cosmelan European is NOT a bleaching cream and contains no hidroquinone.

The Cosmelan® Depigmentation treatment offers a series of major
advantages and benefits compared with other types of depigmentation
•        Very effective in all types of melasma
•        Rapid and easy depigmenting action
•        Compatible with ALL skin types (Fitzpatrick I – VI)
•        Light peeling effect
•        Rejuvenates the skin
•        Treatment can be used all year round
•        Beneficial for acne patients
•        Does not contain TCA
•        High safety margin

Clinical studies conducted by the manufacturers show that: “In 99% of the
cases, the clearance of the blemishes improves by 95%...”  Our own patients
show close to 100% satisfaction.  

TREATMENT APPLICATION - Cosmelan® is a mask applied at our office by a
Physician Assistant and remains on your face 8 to 12 hours depending on the
indication.  The mask is washed off at home and you may expect three to five
days of light to heavy peeling, redness and sensitivity.  After the third or fourth
day, the skin appears healthy and luminous and the marks begin to fade.

ONE WEEK after starting the mask application, a noticeable significant
improvement of the skin is observed! The reduction of the treated blemish is
detected and the appearance of new luminous and rejuvenated skin is present.
At the end of the Cosmelan® Depigmentation treatment, the blemishes start to
disappear altogether, so that, although the you may be able to “locate” the
place where the spot was, the pigmentation is significantly reduced and
nobody will be able to see it just by looking at it.

The Cosmelan Depigmentation treatment is initiated at the medical office but
must be continued at home, on a daily basis, according to the guidelines
indicated.  Because of the nature of pigmentation and melasma, continued
maintenance helps prevent re-pigmentation.  Strict sun avoidance should also
be followed.

HOME TREATMENT - Cosmelan® 2 European Maintenance Cream

The second phase of the Cosmelan treatment consist of a home maintenance
cream Cosmelan 2 with the intention of securing the depigmentation by
association of agents such as Kojic Acid, Phytic Acid, and Vitamin C.    
Cosmelan 2 cream should be applied 2 times per day during the first two
weeks, and once a day from the third week on for several months depending
on the indication as directed to achieve an optimum depigmentation response.

We often reserve some Cosmelan® 1 Mask for a “touch-up” application if
necessary in one month.  This helps achieve excellent results on even the
most stubborn areas.   
Skin Lightening Compounds

Dr. Rubinstein formulates several skin lightening compounds in various
strengths which gradually help address pigmentation.  These prescription
strength formulas lighten uneven skin tone, residual brown pigmentation
caused by acne or other scarring, and require a physician visit to our
practice.    A formula containing Retin-A is also available for patients whose
skin can tolerate a more intense treatment process and who wish to achieve
faster results.  Retin-A also helps achieve cell turnover and improve the texture
of the skin.  This treatment corrects current pigmentation and prevents the
appearance of new pigmentation.  This treatment is indicated for patients who
regularly develop pigmentation from hormones, sun, acne or other factors.  A
consultation with Dr. Rubinstein or a Physician Assistant is required to
determine if you are a candidate for this treatment and to obtain a prescription.
Uneven Texture and Skin Tone
Acne Scarring
Melasma and Pigmentation
The only office in the Los Angeles
area to carry
Cosmelan European
.  Most effective "original"
formula which we combine with a
proprietary pre-treatment procedure
for most effective results on
pigmentation and skin texture.
Cosmelan European Original Formula
Los Angeles Exclusive Provider  
Pigmentation and Melasma
Gene Rubinstein, M.D.
Skin Rejuvenation and
Laser Specialist Los Angeles
(818) 505-9300