DAXXIFY™

Have fine lines and wrinkles got you down? Turn that frown upside down with DAXXIFY™! This injectable is the first FDA-approved peptide-powered frown line treatment that lasts for 6-9 months. This injectable takes only minutes to administer and can leave you feeling young and radiant for the long haul. Why not give it a try today? Connect with us in Studio City or Simi Valley today!

How do frown lines form?

Several factors contribute to the formation of facial lines. Decreased collagen production, cellular changes, genetics, environmental damage, and sun damage may all play a role. Facial lines are also formed by repeated muscle contractions such as frowning, squinting, or raising the eyebrows. These facial expressions cause the skin to furrow and fold, which eventually leads to the formation of wrinkles.
DAXXIFY™ works below the skin’s surface to temporarily reduce the underlying muscle activity responsible for moderate to severe frown lines.

What is DAXXIFY™?

DAXXIFY™ is FDA approved to help smooth moderate to severe lines between the brows. It is the only long-lasting frown line treatment powered by a peptide with results that last on average 6 months and up to 9 months for some.† The active ingredient in DAXXIFY™ is a purified protein called botulinum toxin type A.

†At least 50% of patients in clinical studies had no or minor frown lines 6 months after treatment. Between 3% and 5% of patients in clinical studies had no or minor frown lines 9 months after treatment. In other safety studies, between 5% and 17% of patients still had noticeable improvement 9 months later.

How long has botulinum toxin type A been used in facial aesthetics?

Injectable wrinkle treatments containing botulinum toxin type A have been used to improve the look of moderate to severe frown lines for more than 20 years. The first FDA-approved treatment was BOTOX® Cosmetic, followed by Dysport®, Xeomin®, and Jeuveau®. Although today’s wrinkle reducers all contain botulinum toxin type A, it’s important to know that no two treatments are alike and the doses cannot be interchanged with each other.

Will I need the same number of Units as my current frown line treatment?

In short, no, and here’s why. Units are like fingerprints—they are a proprietary measurement of a treatment’s unique potency. Because of the differences in how treatments are formulated and tested, you cannot compare or convert Units between them, just like you cannot compare 2 fingerprints.
A clearer way to understand dosing is to look at how many nanograms of active ingredient (botulinum toxin type A) a product has. Double the Units does not mean double the dose.

	DAXXIFY™	BOTOX® Cosmetic	DYSPORT®
Approved frown line dose	40 Units	20 Units	50 Units
Amount of active ingredient:	0.18 nanograms	0.18 nanograms	0.27 nanograms

How is DAXXIFY™ different from other frown line treatments?

DAXXIFY™ is powered by a peptide. All frown line treatments require a special ingredient to stabilize botulinum toxin A, the protein responsible for helping smooth moderate to severe frown lines. For instance, BOTOX® Cosmetic uses human serum albumin (HSA), a blood product, as its stabilizer. Dysport®, another frown line treatment, uses cow’s milk protein in addition to HSA.
DAXXIFY™ is unique because it is the only formulation that uses a novel peptide as a stabilizer and does not contain human or animal byproducts.

How often will I need to get DAXXIFY™?

If you’re like most people, you probably get a frown line treatment around twice a year. But here’s the thing: conventional treatments only last 3–4 months. That means you may spend the next 2-3 months of the year with those frown lines staring back at you between treatments. That’s up to 4-6 months of total wear off time per year!

DAXXIFY™ is different. With those same 2 treatment visits, you can keep your frown lines smoother for a full year!§

§At least 50% of patients in clinical studies had no or minor frown lines 6 months after treatment.

Do long-lasting results mean potentially long-lasting side effects?

No, not necessarily. The most common side effects observed in clinical trials occurred within one to two weeks after injection and lasted only a short while. This is consistent with other frown line treatments.

Will I see results quickly?

You may see results with DAXXIFY™ as early as the next day after treatment, and typically within two days.

I have an event coming up in 2 weeks and want to try DAXXIFY™. Is now the right time to get treated?
You may see results with DAXXIFY™ as early as the next day after treatment, and typically within two days. You should see noticeable results within a two-week time frame. You may experience mild injection-related bruising. In most cases, bruising heals within a few days after injection.

How was DAXXIFY™ discovered?

In 2002, physicians and entrepreneurs founded a start-up in Silicon Valley, California to explore the use of peptides in biologics for different therapeutic uses. Their goal was to utilize peptides to transport biologics, typically large molecules, through the skin. The initial idea was to formulate botulinum toxin type A, the active ingredient in DAXXIFY™, with a peptide to see if it could be applied topically to the skin to treat crow’s feet wrinkles. Through this process, scientists discovered that the formulation was optimally administered through injection. Several clinical studies were created to determine the correct dose for an injectable product that would treat frown lines.

How was DAXXIFY™ studied?

DAXXIFY™ was studied in the largest-ever clinical study for a frown line treatment and included more than 2,800 people across different ages and skin types. Here are some things you should know about DAXXIFY™:

• There were no serious treatment-related side effects
• The active ingredient in DAXXIFY^™ is botulinum toxin type A, an ingredient that has been used in frown line treatments for more than 20 years
• 96% of people treated with DAXXIFY^™ were satisfied with their results^‡

^‡96% of patients reported they were satisfied on a 7-point scale when evaluated at 4 weeks in clinical studies.

Where is DAXXIFY™ made?

DAXXIFY^™ is manufactured in California, and the only frown line injectable made in the United States. 

How much does DAXXIFY™ cost?

Dynamic facial wrinkles are treated in muscle groups. For example, frown lines, or 11’s; horizontal lines on the forehead; and lines around the eyes.  Other muscle groups we commonly treat are neck lines and frown lines around the mouth. Sometimes different neuromodulators are used for different areas to achieve best results. Here are the prices for Daxxify as compared to other frown line treatments. 

DAXXIFY^™  $12 per unit or $480 per muscle group, $960 per year*
BOTOX^® $14 to $15 per unit, $280-300 per muscle group or $840-900 per year** 
DYSPORT^® $6 per unit, $300-450 per muscle group or $900-1350 per year** 
JEUVEAU^® $14 per unit, $280 per muscle group or $840 per year**
*based on 2 visits per year
**based on 3 visits per year

DAXXIFY™ Frown Line Treatment in The Greater Los Angeles Area

Treating frown lines with DAXXIFY™ is simple, effective, and transformative. This treatment can restore the youth of your skin without downtime. Dr. Rubinstein is a trained medical professional with a background in effectively administering this and other injectable treatments. When you visit our center, you can rest assured that you are receiving the best possible care in the most capable hands. Schedule a consultation in Studio City or Simi Valley today!

*Individual results may vary; not a guarantee.

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